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The scientists that pioneered the Glycemic Index and broke the key code to the genetic disease, Sickle Cell (United Nations General Assembly/NY), announced today that they have discovered the first metabolic cell-signaling pathway in humans which downregulates Cortisol.

The physicians and researchers responsible for the Cortisol discovery include top genetic specialists from the National Institutes of Health (NIH), Johns Hopkins Medical School, and Encode® scientists.


Encode® Researchers (www.EncodeResearch.com) have spent the past 25 years studying the hypothalamic-pituitary axis and its relationship to aging, genetic diseases, and L-Arginine. They received the first Glycemic patent ever awarded, and the first patent for L-Arginine crossing the Blood-Brain Barrier.

Their groundbreaking research led to the discovery of Blind Amino Acids, and the first safe transport system for amino acids to cross the BBB, instigating the release of the anti-aging hormone, Growth Hormone from the hypothalamus/pituitary.

It was during this research they noted that the neurohormone, Cortisol was under the control of centers sensing blood glucose (glycemic) levels, and was also controlled by the hypothalamic-pituitary axis.

This finding led to the scientists to develop a method for de-coding Cortisol and its negative actions on the human body. In effect, they discovered a mechanism for mitigating the actions of Cortisol, which is known in the biochemical arena as downregulation.

The researchers stated that they intend to utilize this research in the health, nutrition, sports medicine, and Nutraceutical fields by educating companies on methodologies for reformulating foods, beverages, and Nutraceuticals that downregulate Cortisol.

These methodologies include formulae applications involving Low Glycemic, anti-ketogenic glycoside carbohydrates produced from highly refined fruit-extractions, a proprietary process developed and clinically researched in Board Approved Human In Vivo Trials.

The anti-drug sports advocate group, Human Sports Performance®, has officially approved the glycosidic compound for use in sports-related products.

Encode® Research
February 5, 2009



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